Myocardial Recovery in Chronic Heart Failure

Chronic heart failure is a disease with poor prognosis and currently is a global epidemic. University of Utah Health investigator Stavros George Drakos, MD, and colleagues analyzed human heart tissue and produced evidence refuting the widely held notion that prolonged off-loading of the failing heart induced by cardiac assist devices results in disuse atrophy that further deteriorates heart function. Continue reading → Myocardial Recovery in Chronic Heart Failure

Continue reading → Myocardial Recovery in Chronic Heart Failure

Reconstituting HIV Replication in a Test Tube

Reverse transcription and integration are key events in retrovirus replication and are also targets of successful anti-HIV therapies. Reverse transcription creates a double-stranded DNA copy of the viral RNA genome, and integration archives that copy within the genome of the infected cell. However, studies of the mechanisms underlying these steps of the viral life cycle remain challenging because these processes are performed by viral core particles located deep within the infected cell cytoplasm and nucleus. Continue reading → Reconstituting HIV Replication in a Test Tube

Continue reading → Reconstituting HIV Replication in a Test Tube

Megakaryocytes and Platelets in Immune and Inflammatory Responses and in COVID-19

Platelets—small cells which circulate in abundance in the bloodstream—are traditionally known for their ability to form clots and stop bleeding. Recent studies, however, have shown that platelets and their parent cells, megakaryocytes, also play a role in inflammation and infection. University of Utah Health investigators Robert Campbell, PhD, and Matthew Rondina, MD, and colleagues discovered that platelets and megakaryocytes respond robustly to infection, including COVID-19. These infection-driven changes in platelets activate clotting mechanisms and thus may contribute to the blood clots that complicate COVID-19 infection. Continue reading → Megakaryocytes and Platelets in Immune and Inflammatory Responses and in COVID-19

Continue reading → Megakaryocytes and Platelets in Immune and Inflammatory Responses and in COVID-19

Visualizing the SARS-CoV-2 Life Cycle

SARS-CoV-2 is defining disease of the current era. Many biological researchers have redirected their focus to understanding and defeating the virus, rapidly leading to new insights into how the virus gains access to and hijacks human cells. University of Utah Health investigator Janet Iwasa, PhD, and colleagues have used this information to create detailed molecular animations of different stages of the SARS-CoV-2 life cycle. Continue reading → Visualizing the SARS-CoV-2 Life Cycle

Continue reading → Visualizing the SARS-CoV-2 Life Cycle

A Potent, Long-lasting HIV Capsid Inhibitor

Reverse transcription and integration are key events in retrovirus replication and are also targets of successful anti-HIV therapies. Reverse transcription creates a double-stranded DNA copy of the viral RNA genome, and integration archives that copy within the genome of the infected cell. However, studies of the mechanisms underlying these steps of the viral life cycle remain challenging because these processes are performed by viral core particles located deep within the infected cell cytoplasm and nucleus. Continue reading → A Potent, Long-lasting HIV Capsid Inhibitor

Continue reading → A Potent, Long-lasting HIV Capsid Inhibitor

Supporting Health by Screening for Social Needs

Photo for "Supporting Health by Screening for Social Needs" entry, featuring a patient in an exam room being asked questions by a healthcare provider.

When patients struggle to get enough food, lack stable housing, or have limited access to transportation, their health can suffer. One analysis estimated that as much as 50 percent of the variation in health outcomes between counties in the U.S. can be attributed to social determinants of health like these. Such factors can limit the effectiveness of clinical care—but health care workers often don’t know what their patients are dealing with outside the clinic.

Addressing patients’ social needs is not always a priority in busy hospitals and clinics. But Andrea Wallace, PhD, RN, associate dean for research at the College of Nursing, has developed a way to make this a routine aspect of care. With systematic screening, patients’ unmet needs can be identified so clinicians can connect them with services that can help.

Wallace and her U or U Health colleagues have demonstrated that this screening can be done in emergency departments, which see disproportionate numbers of patients who are uninsured and have low incomes. The researchers are focused on finding the best ways to assess for social needs, considering factors such as language barriers, privacy concerns, and potential discomfort for patients and staff. In their most recent study, conducted at a children’s hospital in Salt Lake City, systematic screening allowed the team to identify 1,680 families with unmet social needs in a four-month period.

Wallace and colleagues have also shown how emergency departments can partner with a community service referral network to connect patients and families with services once needs have been identified. By helping secure access to healthy food, finding transportation to medical appointments, or assisting with rent and utilities, they can help patients get on a path to better health.

References:

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Social Needs Screening During Pediatric Emergency Department Visits: Disparities in Unmet Social Needs. Tedford NJ, Keating EM, Ou Z, Holsti M, Wallace AS, Robison JA. Acad Pediatr. 2022 Nov-Dec;22(8):1318-1327. doi: 10.1016/j.acap.2022.05.002.

Integrating social determinants of health screening and referral during routine emergency department care: evaluation of reach and implementation challenges. Wallace AS, Luther BL, Sisler SM, Wong B, Guo JW. Implement Sci Commun. 2021 Oct 7;2(1):114. doi: 10.1186/s43058-021-00212-y.

Implementing a Social Determinants Screening and Referral Infrastructure During Routine Emergency Department Visits, Utah, 2017-2018. Wallace AS, Luther B, Guo JW, Wang CY, Sisler S, Wong B. Prev Chronic Dis. 2020 Jun 18;17:E45. doi: 10.5888/pcd17.190339.

Neuronal Connections in the Retina

Bryan Jones, PhD, and colleagues used electron microscopes to visualize the chemical and electrical synaptic connections that makes up the neural network. They further observed, in a transgenic rabbit model of early retinal degeneration, abnormal connectivity in the rod-photoreceptor network and novel synaptic connections derived from sprouting. Continue reading → Neuronal Connections in the Retina

Continue reading → Neuronal Connections in the Retina

Unexpected Antiviral Activity of Spironolactone

Epstein–Barr virus (EBV) is a human herpesvirus associated with clinical infections and several types of malignancies. Sankar Swaminathan, MD, and colleagues showed that a hypertension/heart failure drug, spironolactone, also has anti-EBV effects. Continue reading → Unexpected Antiviral Activity of Spironolactone

Continue reading → Unexpected Antiviral Activity of Spironolactone

New Class of Therapy for Chronic Heart Failure

The lab directed by Robin Shaw (MD, PhD) and Nora Eccles Harrison Cardiovascular Research & Training Institute (CVRTI) Investigators have identified an architectural protein (cBIN1) of heart muscle cells that organizes the intracellular signalizing network responsible for heart muscle contraction and relaxation. Continue reading → New Class of Therapy for Chronic Heart Failure

Continue reading → New Class of Therapy for Chronic Heart Failure

A Rapidly Manufacturable, Open-Source Ventilator for Austere Conditions

At the beginning of the COVID-19 pandemic, severe ventilator shortages led to dire situations both in developed regions and in low-resource regions where robust and affordable ventilators were already scarce. To address this urgent need, University of Utah Health researcher Kai Kuck, PhD, and colleagues developed Pufferfish, a complete intensive care unit ventilator capable of supporting the continuum from noninvasive ventilation to full mechanical ventilation. Continue reading → A Rapidly Manufacturable, Open-Source Ventilator for Austere Conditions

Continue reading → A Rapidly Manufacturable, Open-Source Ventilator for Austere Conditions

Enhancing Decision-making for Diagnosis and Management of Respiratory Infection

Barbara Jones, MD, and Matthew Samore, MD, used national data from the Department of Veterans Affairs to examine decision-making and practice patterns among providers prescribing antibiotics for patients diagnosed with acute respiratory infection. Continue reading → Enhancing Decision-making for Diagnosis and Management of Respiratory Infection

Continue reading → Enhancing Decision-making for Diagnosis and Management of Respiratory Infection

Lipid Metabolism and Cardiometabolic Disease

Metabolic diseases such as diabetes, steatohepatitis, and coronary artery disease result from the delivery of nutrients that exceed a tissue’s energetic needs or storage capacity. The excess nutrients give rise to deleterious lipid species that impair cellular function. Summers and colleagues found that ceramides, a class of sphingolipids, alter the metabolism of liver and adipose tissue in a way that gives rise to cardiometabolic disease. Continue reading → Lipid Metabolism and Cardiometabolic Disease

Continue reading → Lipid Metabolism and Cardiometabolic Disease

Causes of Type 1 Diabetes

More than 1 million Americans suffer from Type 1 diabetes, which occurs when a patient’s immune T cells attack their pancreas. Understanding why this occurs is key to developing treatments that target the cause and not just the symptoms of diabetes. Continue reading → Causes of Type 1 Diabetes

Continue reading → Causes of Type 1 Diabetes

How Cells Choose to Create Energy

To supply their energy needs, cells typically choose between utilizing glucose in the cytoplasm (aerobic glycolysis and lactic acid fermentation) or “burning” pyruvate in the mitochondria (mitochondrial carbohydrate oxidation). Although this is arguably the most fundamental metabolic decision that cells make, before 2012 it was not clear how cells import pyruvate into mitochondria to fuel ATP production. Continue reading → How Cells Choose to Create Energy

Continue reading → How Cells Choose to Create Energy

How Iron Deficiency Impairs Pancreatic β-Cell Function

Research in the lab of Elizabeth Leibold, PhD, showed that in mice with iron deficiency, proinsulin processing to mature insulin was impaired, resulting in reduced levels of circulating and glucose intolerance. Mice treated with iron restored insulin to normal levels and eliminated the glucose intolerance. Continue reading → How Iron Deficiency Impairs Pancreatic β-Cell Function

Continue reading → How Iron Deficiency Impairs Pancreatic β-Cell Function