The Sundquist lab studies the cellular, molecular and structural biology of retroviruses, particularly HIV, and the roles of the ESCRT pathway in cell division and the abscission checkpoint. Major projects in our lab include studies of:
1) ESCRT pathway functions and regulation in cell division and cancer
2) HIV budding
3) HIV capsid structure, function and restriction, particularly by the TRIM5α system
4) Designed enveloped protein nanoparticles
Our approaches include NMR, EM, crystallographic and computational studies of viral complexes, identification and biochemical analyses of the interactions between viral components and their cellular partners, and genetic analyses of viral and cellular protein functions.