Jared P. Rutter, PhDLink: More info
Bio: Jared P. Rutter, PhD. Department of Biochemistry. University of Utah Health. Member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute.
The Rutter laboratory is interested in discovering new ways to understand metabolism and how it integrates with cell behavior. We are currently exploring two central areas.
First, as much of metabolic control is enacted at the level of mitochondria—in ways that are mostly not understood—we initiated a project to functionally annotate the eukaryotic mitochondrial proteome. To date, this effort has elucidated the genetic basis of two human diseases and several fundamental mitochondrial functions.
Second, we are leveraging this knowledge to explore the connection between metabolism and cellular behaviors. Specifically, we want to determine how alterations in distinct metabolic pathways can impact cell fate decisions both in discrete stem cell niches as well as in human diseases such as cancer and heart failure. To facilitate this undertaking we are developing several experimental and computational platforms for the identification and characterization of novel features of metabolism.