MicroRNA Regulation of Inflammation and Immunity

MicroRNAs provide a crucial level of control for cell development and function through their post-transcriptional regulation of gene expression. Their importance is highlighted by their diverse functions in a range of cell types, including immune cells. Continue reading → MicroRNA Regulation of Inflammation and Immunity

Viral RNA Modulation of Host Gene Expression

Viruses depend on and modulate their hosts’ cellular environments to maximize replication. Cazalla and colleagues studied the small RNAs from H. saimiri, a herpesvirus that establishes latency in the T cells of New World primates and can cause aggressive leukemias and lymphomas in non-natural hosts. Continue reading → Viral RNA Modulation of Host Gene Expression

Regulation of Innate Immune Pathways

Cells must regulate their innate immune pathways so that they can respond rapidly to pathogens, yet avoid aberrant activation that can lead to inflammation. The evolution of these regulatory mechanisms remains to be understood. Continue reading → Regulation of Innate Immune Pathways