Neuronal Connections in the Retina

Bryan Jones, PhD, and colleagues used electron microscopes to visualize the chemical and electrical synaptic connections that makes up the neural network. They further observed, in a transgenic rabbit model of early retinal degeneration, abnormal connectivity in the rod-photoreceptor network and novel synaptic connections derived from sprouting. Continue reading → Neuronal Connections in the Retina

Architecture of the Inner Ear

Normal hearing is dependent upon a highly specialized structure in the inner ear called the tectorial membrane. How this precisely organized extracellular matrix is assembled had been unknown. However, Park and colleagues showed the inner ear membrane anchors to the cell surface during development and grows one layer at a time. Continue reading → Architecture of the Inner Ear

Neuronal Circuits that Modulate Pain and Defensive Responses

Understanding pain-processing mechanisms and the neural circuits involved is central to developing new therapeutic strategies for the treatment of pain. The Douglass lab investigated brain regions that modulate behavioral responses to noxious stimuli in zebrafish. Continue reading → Neuronal Circuits that Modulate Pain and Defensive Responses