We are particularly interested in the elucidation of the protein machinery at the synapse and the basic cell biological processes that mediate long-term storage of information. In addition, we are investigating how these process go awry in neurodevelopmental disorders such as Angelman Syndrome and in cognitive decline during aging.

The overall goal of our research program is to investigate the role of activity-dependent processes, and the requisite gene programs, involved in synaptic plasticity and how these processes go awry in neurological disorders.

Shepherd Lab