Research Statement

The Evavold Lab is focused on studying how T cells interact with their antigens. Through the use of our novel and sensitive Micropipette assay we are able to determine single bond T Cell Receptor (TCR) affinity for peptide restricted by MHC (pMHC) in T cell subset populations. Our Biomembrane Force Probe is able to analyze TCR:pMHC bond lifetimes under force. Together, Micropipette and BFP analysis of cells provide a clearer picture of T cell interactions with antigens associated with self and pathogens.

Brian Evavold Lab