Brian Evavold, PhD

Causes of Type 1 Diabetes

More than 1 million Americans suffer from Type 1 diabetes, which occurs when a patient’s immune T cells attack their pancreas. Understanding why this occurs is key to developing treatments that target the cause and not just the symptoms of diabetes. Continue reading → Causes of Type 1 Diabetes

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Bio: Brian Evavold, PhD, Department of Pathology, School of Medicine, University of Utah.

Research Statement

The Evavold Lab is focused on studying how T cells interact with their antigens. Through the use of our novel and sensitive Micropipette assay we are able to determine single bond T Cell Receptor (TCR) affinity for peptide restricted by MHC (pMHC) in T cell subset populations. Our Biomembrane Force Probe is able to analyze TCR:pMHC bond lifetimes under force. Together, Micropipette and BFP analysis of cells provide a clearer picture of T cell interactions with antigens associated with self and pathogens.

Brian Evavold Lab