Identifying RNAs from Invading Viruses

Biochemical and structural studies from Bass, Shen, Iwasa, and colleagues revealed how Dicer-2, an RNA processing, and antiviral defense enzyme, distinguishes and differentially processes double-stranded RNA (dsRNA) substrates by sensing the unique chemistry at their termini. Continue reading → Identifying RNAs from Invading Viruses

Viral RNA Modulation of Host Gene Expression

Viruses depend on and modulate their hosts’ cellular environments to maximize replication. Cazalla and colleagues studied the small RNAs from H. saimiri, a herpesvirus that establishes latency in the T cells of New World primates and can cause aggressive leukemias and lymphomas in non-natural hosts. Continue reading → Viral RNA Modulation of Host Gene Expression

Regulation of Innate Immune Pathways

Cells must regulate their innate immune pathways so that they can respond rapidly to pathogens, yet avoid aberrant activation that can lead to inflammation. The evolution of these regulatory mechanisms remains to be understood. Continue reading → Regulation of Innate Immune Pathways