Identifying RNAs from Invading Viruses

Biochemical and structural studies from Bass, Shen, Iwasa, and colleagues revealed how Dicer-2, an RNA processing, and antiviral defense enzyme, distinguishes and differentially processes double-stranded RNA (dsRNA) substrates by sensing the unique chemistry at their termini. Continue reading → Identifying RNAs from Invading Viruses

Research Statement

We study double-stranded RNA (dsRNA)–its biological functions and the proteins that bind it to mediate these functions.

Our studies are divided between two dsRNA-mediated pathways: RNA editing by adenosine deaminases that act on RNA (ADARs), and Dicer-mediated gene silencing.

Bass Lab