Sensing and Regulating Cellular Energy Production

Cells must decide when to expand mitochondrial capacity to accommodate increased energy demands. Rutter, Winge, and colleagues have shown that the ancient mitochondrial fatty acid synthesis system has a profound and unexpected regulatory role in driving mitochondrial biogenesis. Continue reading → Sensing and Regulating Cellular Energy Production

Cellular Membrane Remodeling

Cells are continually severing, fusing, and reshaping their membranes. One of the essential cellular membrane remodeling systems is the ESCRT (Endosomal Sorting Complexes Required for Transport) pathway, whose cellular functions include endosomal membrane remodeling, membrane repair, enveloped virus budding, closure of the nuclear envelope, and cytokinetic abscission. Continue reading → Cellular Membrane Remodeling