Cellular Membrane Remodeling

Cells are continually severing, fusing, and reshaping their membranes. One of the essential cellular membrane remodeling systems is the ESCRT (Endosomal Sorting Complexes Required for Transport) pathway, whose cellular functions include endosomal membrane remodeling, membrane repair, enveloped virus budding, closure of the nuclear envelope, and cytokinetic abscission. Continue reading → Cellular Membrane Remodeling

Research Statement

Our lab strives to see how macromolecules get together and come to life. We seek to understand how fuel-driven biological machines work–especially those that are too fragile to purify, too dynamic or too flexible to crystallize, and that depend on lipids for their form and function. To derive unique insights into cell biology, we integrate atomic structure determination by cryoEM with genetics, biochemistry, and other imaging techniques. We work within the department of Biochemistry and Biophysics the Macromolecular Structure Group and the Quantitative Biosciences Institute (University of California, San Diego).

Frost Lab