Mechanisms of Circulatory Abnormalities and Fatigue in Patients with Cardiovascular Diseases

Markus Amann, PhD, and colleagues recently discovered that both heart failure and hypertension impair an important neurocirculatory control mechanism in humans—specifically, a reflex loop mediated by neural feedback from muscles to the central nervous system. This impairment results in excessive sympathetic nervous system activity, and largely accounts for the circulatory abnormalities observed during physical activities. Continue reading → Mechanisms of Circulatory Abnormalities and Fatigue in Patients with Cardiovascular Diseases

Research Statement

Dr. Amann is a Professor of Anesthesiology, Theodore H. Stanley Presidential Endowed Chair in Anesthesiology, and Adjunct Professor in the Departments of Internal Medicine and Biomedical Engineering. His research focuses on the neural control of the circulation and breathing, and the etiology of central nervous system fatigue. Dr. Amann’s work aims at enhancing our understanding of the impact of cardiovascular disease on autonomic reflex function and of mechanisms determining neuromuscular fatigue during physical activity. More information about Dr. Amann’s research can be found at the Utah Vascular Research Laboratory.