Posted on | CategoriesDiabetes and Metabolism / Internal Medicine | PI: Simon J. Fisher, MD, PhD , Owen Chan, PhD & Candace M. Reno, PhD

Neural and Cardiac Responses to Hypoglycemia

The laboratories of Simon Fisher, MD, Owen Chan, PhD, and Candace Reno, PhD, demonstrated that brain glucose sensing was impaired in rats with recurrent hypoglycemia as a result of defective glucose and lactate metabolism within the neurons and astrocytes in the hypothalamus. The resultant abnormal release of neurotransmitters—such as GABA, glutamate and dopamine—led to inadequate activation of hormonal responses to hypoglycemia. Continue reading → Neural and Cardiac Responses to Hypoglycemia

Research Statement

I conduct basic science research studies to understand how low blood sugar due to the treatment of diabetes can lead to cardiac arrhythmias with the goal to find treatments to prevent these devastating complications. This research is important to better the lives of those affected by diabetes that are at risk for hypoglycemia.