Discovery and Innovation at University of Utah Health
Digital Collection
An important area of research involves learning how gene expression influences health and disease risks. The parts of the genome that regulate gene expression are cis-regulatory elements. Gregg and colleagues took an unusual approach to discover these cis-regulatory elements by analyzing the genomes of species that evolved disease resistance “superpowers”. Continue reading → Gene Expression and Health Risks
Continue reading → Gene Expression and Health RisksWell curated human pedigrees like the iconic pedigrees maintained by the Centre d’Etude du Polymorphism Humain (CEPH) provide an invaluable resource for fundamental discoveries in human genetics and health. The CEPH collection includes families collected by R. White (Utah), J. Dausset (French), J. Gusella (Venezuelan), and J. Egeland (Amish). Continue reading → Analyzing Human Pedigrees to Advance Genetics and Health
Continue reading → Analyzing Human Pedigrees to Advance Genetics and HealthTobacco cessation substantially reduces the risk of cancer and other diseases, but evidence-based tobacco cessation treatments are currently underutilized. Continue reading → Improving Tobacco Cessation Program Utilization
Continue reading → Improving Tobacco Cessation Program UtilizationCells must regulate their innate immune pathways so that they can respond rapidly to pathogens, yet avoid aberrant activation that can lead to inflammation. The evolution of these regulatory mechanisms remains to be understood. Continue reading → Regulation of Innate Immune Pathways
Continue reading → Regulation of Innate Immune PathwaysHosts and pathogens are locked in an endless battle to gain selective advantages over one another. Host-pathogen interactions, therefore, provide valuable systems for studying evolutionary genetics, natural selection, microbiology, and infectious disease. Continue reading → Host-Microbe Battles Over Iron
Continue reading → Host-Microbe Battles Over Iron