Posted on | CategoriesCardiovascular | PI: TingTing Hong, MD, PhD & Robin M. Shaw, MD, PhD

Regulation and Remodeling of Membrane Microdomains of Cardiomyocytes During Heart Failure Progression

At U of U Health, scientists are learning how the molecular organization of heart cells changes as heart failure progresses, and using that knowledge to pioneer potential gene therapy for heart disease. Continue reading → Regulation and Remodeling of Membrane Microdomains of Cardiomyocytes During Heart Failure Progression
Posted on | CategoriesBiomedical Informatics / Human Genetics / Internal Medicine | PI: Mark Yandell, PhD , Martin Tristani-Firouzi, MD & Karen Eilbeck, PhD

Teasing Apart Effects of Comorbid Conditions on Cardiovascular Health

Understanding the complex clinical variables that drive cardiovascular health outcomes in patients with multiple conditions poses a major challenge for personalized medicine. Continue reading → Teasing Apart Effects of Comorbid Conditions on Cardiovascular Health
Posted on | CategoriesNutrition & Integrative Physiology | PI: J. David Symons, PhD & Sihem Boudina, PhD

Late-in-life Exercise Training Increases Intracellular Protein Recycling in the Heart

Heart cells (known as myocytes) work hard. Over a human lifetime, the heart beats approximately 2.5 billion times. As myocytes age, and especially in the presence of disease, they accumulate damaged intracellular components such as misfolded proteins. This build-up of damaged cellular material can cause cardiac dysfunction, diminish quality of life, and lead to premature death. Continue reading → Late-in-life Exercise Training Increases Intracellular Protein Recycling in the Heart
Posted on | CategoriesPrevention / Surgery | PI: Benjamin Brooke, MD

Individualized Venous Thromboembolism Risk Stratification and Chemoprophylaxis in Surgical Patients

The research team of Christopher Pannucci, MD, and Benjamin Brooke, MD, set out to determine whether chemoprophylaxis for VTE among surgical patients could be better achieved through individualized risk stratification using established Caprini scores. They performed a meta-analysis of nearly 15,000 surgery patients, stratified by Caprini scores for VTE risk levels. Continue reading → Individualized Venous Thromboembolism Risk Stratification and Chemoprophylaxis in Surgical Patients