Posted on | CategoriesDrug Discovery / Medicinal Chemistry | PI: Raphael Franzini, PhD

Developing New Chemical Reactions that Can Be Performed in Living Cells

The development of bioorthogonal chemical reactions—chemical reactions that can be conducted in living cells—has been one of the most significant areas of advancement in chemistry in recent years. Franzini and colleagues have developed a series of highly efficient chemical reactions, termed “dissociative bioorthogonal reactions”, that do just that. Continue reading → Developing New Chemical Reactions that Can Be Performed in Living Cells

Research Statment

Addressing the current challenges faced by clinicians will require an interdisciplinary approach combining knowledge of diverse fields. The Franzini research group focuses on the interfaces of Chemistry, Biology and Medicine with the aim of developing novel types of therapeutic agents, imaging probes and diagnostic assays. Standard experimental techniques used to achieve this goal include synthetic organic chemistry, instrumental analysis, and basic molecular biology methods.