Research in the Kohan lab, using genetically engineered mice, has helped identify the peptide, endothelin-1, and its receptor, ETA, as key regulators of blood pressure and kidney function in health. They have also helped determine that kidney ET-1 production is increased in many kidney diseases and, via activation of ETA receptors on most kidney cell types, leads to inflammation, scarring and decreased kidney function. Continue reading → Finding New Ways to Treat Kidney Disease