Mechanisms of Epigenetic Inheritance

A central issue in epigenetics is whether and how epigenetic information in gametes (sperm and egg) is inherited. Cairns and colleagues discovered that “Placeholder” nucleosomes, containing histone variants, occupy DNA regions lacking methylation in both sperm and early embryos. Continue reading → Mechanisms of Epigenetic Inheritance

Vascular Inflammation in Malaria Pathogenesis

The pathogenesis of malaria is characterized by vascular inflammation exacerbated by immune cells that travel to areas where red blood cells infected with parasites stick to the endothelium lining the blood vessels. The Lamb lab has made significant discoveries demonstrating a key role for receptor tyrosine kinase family Eph receptors in malaria pathogenesis. Continue reading → Vascular Inflammation in Malaria Pathogenesis