The mission of our laboratory is the development of therapeutics for inherited diseases of the nervous system with an emphasis on spinocerebellar ataxias, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease. Our work on SCA2 represents an effort funded more than two decades by the NINDS. It began when Dr. Pulst and a colleague Dr. Sid Starkman visited a large SCA2 family in Syracuse NY in the early 1990’s. Later with other groups the SCA2 gene was mapped to Chr. 12, and Drs. Pulst and Starkman demonstrated anticipation in the original family suggesting that the causative gene mutation was likely a repeat expansion (Pulst et al., 1993). The gene discovery was published shortly thereafter (Pulst et al., 1996). The discovery demonstrated that ATXN2 had an expanded CAG repeat encoding a polyglutamine, and that ATXN2 is a highly evolutionarily conserved gene. At the time, the only hint on the function of ATXN2 was that it had RNA binding domains. Subsequent work to characterize ATXN2 followed two directions of investigation, discovery of ATXN2 interacting proteins, and the production and characterization of SCA2 mouse models. Chronologically there was much overlap in these efforts.