Lowering Body Temperature After Cardiac Arrest

Hypothermia (lowering the body temperature to subnormal levels) after cardiac arrest became standard practice in adult and neonatal critical care in the early 2000s, but its benefits in children were unknown. To answer this question, University of Utah Health researcher J. Michael Dean, MD, and colleagues conducted two randomized trials (in-hospital and out-of-hospital) at 38 U.S. and international sites, comparing hypothermia with normothermia—maintenance of normal body temperature—after cardiac arrest. Over 4,000 children were screened and 624 participated in the trials. In both trials, researchers found no benefit from hypothermia versus normothermia. Continue reading → Lowering Body Temperature After Cardiac Arrest

Research Statement

Dr. Dean is Professor and Vice Chairman for Research in the Department of Pediatrics at the University of Utah School of Medicine. He directs the Clinical Trials Office in the Department, and serves as the Associate Dean for Clinical Research at University of Utah Health. He attended Northwestern University Medical School (1977) and performed his pediatric residency and chief residency at Children’s Hospital of Los Angeles. Dr. Dean obtained critical care fellowship training at The Johns Hopkins Hospital in 1981, and remained on faculty as an Assistant Professor until 1987, when he was recruited to Utah to assume the roles of Chief of the Division of Pediatric Critical Care at the University of Utah and Medical Director of the Pediatric Intensive Care Unit at Primary Children’s Hospital. He served as interim Department Chairman and hospital Medical Director from 1994 to 1996.

Dr. Dean’s current research interests relate to multicenter observational and interventional clinical trials after pediatric critical and emergency care. He is the principal investigator for the National EMSC Data Analysis Resource Center and the Central Data Management and Coordinating Center for the Pediatric Emergency Care Applied Research Network (both funded by the Maternal and Child Health Bureau EMSC program). He is also the principal investigator for the Pediatric Critical Care Scientist Development Program (K12) and the Data Coordinating Center for the Collaborative Pediatric Critical Care Research Network (both funded by the National Institute for Child Health and Human Development). He was the principal investigator for the Data Coordinating Center of the NHLBI-funded Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trials. He is also the principal investigator for the Utah Trial Innovation Center, designed to improve the national clinical trials infrastructure (funded by the National Center for Accelerating Translational Research).