Inhibiting Neutrophil Extracellular Traps (NETs) in Immune Injury and Pathologic Clotting

Deficient or excess immune system activities cause many human diseases. To understand the mechanisms of immune injury and their links to pathologic clotting, University of Utah Health investigators Christian Yost, MD, Guy Zimmerman, MD, and colleagues defined features of neutrophil extracellular traps (NETs). Continue reading → Inhibiting Neutrophil Extracellular Traps (NETs) in Immune Injury and Pathologic Clotting

Dr. Middleton is an Assistant Professor on the Tenure Track in the Department of Internal Medicine, Division of Pulmonary Medicine. Her research interests are focused on understanding platelet and megakaryocyte reprogramming in the setting of sepsis and acute lung injury and the contribution of these cells to the pathophysiology of these clinical syndromes.”

Our research program focuses on platelet and megakaryocyte gene expression and function during thrombo-inflammatory syndromes.  To answer clinically-relevant questions, we utilize primary human cells and samples from patients as well as relevant experimental model systems.  Current projects in the lab span from studies in patients with infectious diseases (e.g. sepsis, dengue, influenza) to aging and cardiometabolic disorders.

Rondina Lab