Genetic Risk for Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is characterized by excessive androgen hormone, irregular menstrual cycles, and polycystic ovaries on ultrasound. Affected women also frequently experience metabolic disturbances, including obesity, and face increased risk for type 2 diabetes. University of Utah Health investigator Corrine Welt, MD, and collaborators performed an international meta-analysis of whole genome association studies combining over 10 million genetic markers in more than 10,000 European women with PCOS and 100,000 controls. Continue reading → Genetic Risk for Polycystic Ovary Syndrome

Research Statement

Female reproductive disorders are devastating and their underlying etiologies may present additional medical problems within and beyond the reproductive years. My work has therefore focused on disorders of reproduction and their medical consequences. Polycystic ovary syndrome causes infertility because of its irregular menstrual cycles. It is also associated with risk for diabetes, high blood pressure, insulin resistance and high cholesterol. Hypothalamic amenorrhea, which can result from too much exercise or too little fat, causes infertility and bone loss. Women who go through menopause too early are at risk for bone loss and heart disease. My goal is to find markers and genetic risk factors that will help identify these problems early. If diagnosed early, the appropriate prevention and treatment measures can be put in place to alleviate infertility and avoid the associated medical consequences.