Female reproductive disorders are devastating and their underlying etiologies may present additional medical problems within and beyond the reproductive years. My work has therefore focused on disorders of reproduction and their medical consequences. Polycystic ovary syndrome causes infertility because of its irregular menstrual cycles. It is also associated with risk for diabetes, high blood pressure, insulin resistance and high cholesterol. Hypothalamic amenorrhea, which can result from too much exercise or too little fat, causes infertility and bone loss. Women who go through menopause too early are at risk for bone loss and heart disease. My goal is to find markers and genetic risk factors that will help identify these problems early. If diagnosed early, the appropriate prevention and treatment measures can be put in place to alleviate infertility and avoid the associated medical consequences.