A Rapidly Manufacturable, Open-Source Ventilator for Austere Conditions

At the beginning of the COVID-19 pandemic, severe ventilator shortages led to dire situations both in developed regions and in low-resource regions where robust and affordable ventilators were already scarce. To address this urgent need, University of Utah Health researcher Kai Kuck, PhD, and colleagues developed Pufferfish, a complete intensive care unit ventilator capable of supporting the continuum from noninvasive ventilation to full mechanical ventilation. Continue reading → A Rapidly Manufacturable, Open-Source Ventilator for Austere Conditions

Mechanisms of Circulatory Abnormalities and Fatigue in Patients with Cardiovascular Diseases

Markus Amann, PhD, and colleagues recently discovered that both heart failure and hypertension impair an important neurocirculatory control mechanism in humans—specifically, a reflex loop mediated by neural feedback from muscles to the central nervous system. This impairment results in excessive sympathetic nervous system activity, and largely accounts for the circulatory abnormalities observed during physical activities. Continue reading → Mechanisms of Circulatory Abnormalities and Fatigue in Patients with Cardiovascular Diseases