Determinants of Fat Tissue Expansion

Unanticipated heterogeneity in the cell populations that comprise adipose depots.

Adipose tissue (fat) is a complicated organ that can undergo massive expansion in response to nutritional overload. The Boudina lab discovered adipose progenitors with potent anti-adipogenic potential. These cells, which are unique to visceral fat and found in both humans and mice, could explain the propensity of visceral fat to grow by hypertrophy in response to caloric excess. They also identified a set of regulatory events that control healthy adipose expansion. This finding of heterogeneity in the adipose tissue reveals potential opportunities for therapeutic intervention to enable healthy adipose expansion and combat cardiometabolic disease.


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Identification of a paracrine signaling mechanism linking CD34High progenitors to the regulation of visceral fat expansion and remodeling. Buffolo M, Pires KM, Ferhat M, Ilkun O, Makaju A, Achenbach A, Bowman F, Atkinson DL, Holland WL, Amri EZ, Chaurasia B, Franklin S, Boudina S. Cell Rep. 2019 Oct;29(2):270.